0778 Functional thalamo-cortical connectivity relates to sleep-onset problems in early infancy

Abstract Introduction Healthy sleep patterns are crucial for proper brain development in infancy. However, little is known about the relationship between early disturbances and functional connectivity. The thalamus plays a critical role regulation of wakefulness, undergoes rapid growth first year. Therefore, we examined how thalamic connectivity relates to sleep-onset problems during 6 months life. Methods All data were collected as part Baby Connectome Project (1U01MH110274). Forty-six infants (between 3-5 old) underwent resting-state fMRI scans natural sleep. preprocessed analyzed using FSL, bilateral was used seed-based analyses. Infant Behavior Questionnaire (IBQ) create measure initiation. Five IBQ items (21-25) reverse-scored averaged generate Sleep-Onset Problems (ISOP) score, with higher scores indicating longer latencies. ISOP across 3-6 regressors whole-brain Results Preliminary results suggest positive correlation precuneus, such that greater associated stronger precuneus. In contrast, there negative anterior cingulate cortex, fewer cortex. Conclusion Our findings region involved perception integration information, related initiation difficulties. attention allocation emotional regulation, less problems. While these preliminary, they indicate altered thalamo-cortical networks. Support (if any)